FOR 2093

New FOR2093 publication of subproject C1

Hippocampal Dentate Gyrus Atrophy Predicts Pattern Separation Impairment in Patients with LGI1 Encephalitis

The structure-function relationship and contribution of hippocampal subfields to pattern separation was elucidated by examining patients with the rare LGI1 encephalitis showing lesions to hippocampal subfields. Structural sequelae were determined by hippocampal subfield volumetry for the DG, CA1, and CA2/3. Patients showed an overall memory deficit including a significant reduction in pattern separation performance. These results corroborate the framework of a regional specialization of hippocampal functions involved in cognitive processing.